-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction
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چکیده
Chunling Li, Yimin Shi, Weidong Wang, Chrysanthi Sardeli, Tae-Hwan Kwon, Klaus Thomsen, Thomas Jonassen, Jens Christian Djurhuus, Mark A. Knepper, Søren Nielsen, and Jørgen Frøkiær The Water and Salt Research Center, Institute of Clinical Medicine, and Institute of Anatomy, University of Aarhus, Aarhus; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu, Korea; Department of Biological Psychiatry, Institute for Basic Psychiatric Research, Risskov; Department of Pharmacology, University of Copenhagen, Copenhagen; Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital-Skejby, Aarhus N, Denmark
منابع مشابه
alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction.
The purpose of this study was to evaluate the effects of the anti-inflammatory hormone alpha-melanocyte-stimulating hormone (alpha-MSH) treatment on renal function and expression of aquaporins (AQPs) and Na-K-ATPase in the kidney in response to 24 h of bilateral ureteral obstruction (BUO) or release of BUO (BUO-R). In rats with 24-h BUO, immunoblotting revealed that downregulation of AQP2 and A...
متن کاملCOX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.
Bilateral ureteral obstruction (BUO) is associated with marked changes in the expression of renal aquaporins (AQPs) and sodium transport proteins. To examine the role of prostaglandin in this response, we investigated whether 24-h BUO changed the expression of cyclooxygenases (COX-1 and -2) in the kidney and tested the effect of the selective COX-2 inhibitor parecoxib (5 mg.kg(-1).day(-1) via o...
متن کاملAngiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction.
The renin-angiotensin system is well known to be involved in the pathophysiological changes in renal function after obstruction of the ureter. Previously, we demonstrated that bilateral ureteral obstruction (BUO) is associated with dramatic changes in the expression of both renal sodium transporters and aquaporin water channels (AQPs). We now examined the effects of the AT(1)-receptor antagonis...
متن کاملCandesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction.
Angiotensin II (ANG II) plays an important role in the development of obstructive nephropathy. Here, we examined the effects of the ANG II receptor type 1 (AT1R) blockade using candesartan on long-term renal molecular and functional changes in response to partial unilateral ureteral obstruction (PUUO). Newborn rats were subjected to severe PUUO or sham operation (Sham) within the first 48 h of ...
متن کاملCOX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.
Release of bilateral ureteral obstruction (BUO) is associated with reduced expression of renal aquaporins (AQPs), polyuria, and impairment of urine-concentrating capacity. Recently, we demonstrated that 24 h of BUO is associated with increased cyclooxygenase (COX)-2 expression in the inner medulla (IM) and that selective COX-2 inhibition prevents downregulation of AQP2. In the present study, we...
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تاریخ انتشار 2005